BACTERIA ARE EXCELLENT CANDIDATES FOR CANCER THERAPY
MY CURRENT PROJECTS
OPTIMIZING TUMOR-PENETRATING BACTERIA FOR CHALLENGING BREAST CANCERS
BIOPHYSICAL CHARACTERIZATION OF TUMOR CELLS WITH IMMUNE CELLS IN PRESENCE OF BACTERIA FACTORS
BIOPHYSICAL CHARACTERIZATION OF TUMOR CELLS WITH IMMUNE CELLS IN PRESENCE OF BACTERIA FACTORS
Bacteria-based cancer therapies (BBCT) often face poor intratumoral transport due to dense extracellular barriers. My research focuses on engineering bacterial strains with enhanced penetration in solid tumors. I accomplish this by improving their matrix-modifying ability, motility, and metabolic fitness, ultimately aiming to achieve deeper tissue access and more effective drug delivery.
BIOPHYSICAL CHARACTERIZATION OF TUMOR CELLS WITH IMMUNE CELLS IN PRESENCE OF BACTERIA FACTORS
BIOPHYSICAL CHARACTERIZATION OF TUMOR CELLS WITH IMMUNE CELLS IN PRESENCE OF BACTERIA FACTORS
BIOPHYSICAL CHARACTERIZATION OF TUMOR CELLS WITH IMMUNE CELLS IN PRESENCE OF BACTERIA FACTORS
Understanding how BBCT interacts with the tumor immune environment is key to improving outcomes. My research uses live-cell imaging and image analysis to study how breast cancer cells respond to bacterial signals and immune cells, focusing on changes in cell behavior and fate. These insights support the development of more effective, immune-informed BBCT strategies.
MICROFLUIDIC DEVICES FOR SCREENING CANCER THERAPIES
BIOPHYSICAL CHARACTERIZATION OF TUMOR CELLS WITH IMMUNE CELLS IN PRESENCE OF BACTERIA FACTORS
MICROFLUIDIC DEVICES FOR SCREENING CANCER THERAPIES
To screen candidate for BBCT I apply a perfused microfluidic platform to recreate key features of the tumor microenvironment such as nutrient flow, and spatial gradients. These systems enable real-time visualization of bacterial behavior and tumor cell responses under controlled flow, offering a more physiologically relevant model to study BBCT dynamics and refine therapeutic strategies before in vivo testing.